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Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice

Organic anion transporting polypeptide 1a1 (Oatp1a1) is predominantly expressed in liver and is able to transport bile acids (BAs) in vitro. Male Oatp1a1-null mice have increased concentrations of taurodeoxycholic acid (TDCA), a secondary BA generated by intestinal bacteria, in both serum and livers...

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Bibliografski detalji
Glavni autori: Zhang, Youcai, Limaye, Pallavi B., Lehman-McKeeman, Lois D., Klaassen, Curtis D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319588/
https://ncbi.nlm.nih.gov/pubmed/22496825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034522
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