The Neisseria meningitidis CRISPR-Cas9 System Enables Specific Genome Editing in Mammalian Cells

Por Lee, Ciaran M, Cradick, Thomas J, Bao, Gang
Publicado no Mol Ther (2016)

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

Por Cradick, Thomas J., Fine, Eli J., Antico, Christopher J., Bao, Gang
Publicado em 2013

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

Por Lee, Ciaran M, Cradick, Thomas J, Fine, Eli J, Bao, Gang
Publicado no Mol Ther (2016)

Nanomedicine: Tiny Particles and Machines Give Huge Gains

Por Tong, Sheng, Fine, Eli J., Lin, Yanni, Cradick, Thomas J., Bao, Gang
Publicado em 2013

ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites

Por Cradick, Thomas J, Ambrosini, Giovanna, Iseli, Christian, Bucher, Philipp, McCaffrey, Anton P
Publicado em 2011

An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

Por Fine, Eli J., Cradick, Thomas J., Zhao, Charles L., Lin, Yanni, Bao, Gang
Publicado em 2014

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

Por Cradick, Thomas J, Qiu, Peng, Lee, Ciaran M, Fine, Eli J, Bao, Gang
Publicado no Mol Ther Nucleic Acids (2014)

Zinc-finger Nucleases as a Novel Therapeutic Strategy for Targeting Hepatitis B Virus DNAs

Por Cradick, Thomas J, Keck, Kathy, Bradshaw, Shannon, Jamieson, Andrew C, McCaffrey, Anton P
Publicado em 2010

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

Por Mussolino, Claudio, Alzubi, Jamal, Fine, Eli J., Morbitzer, Robert, Cradick, Thomas J., Lahaye, Thomas, Bao, Gang, Cathomen, Toni
Publicado em 2014

SAPTA: a new design tool for improving TALE nuclease activity

Por Lin, Yanni, Fine, Eli J., Zheng, Zhilan, Antico, Christopher J., Voit, Richard A., Porteus, Matthew H., Cradick, Thomas J., Bao, Gang
Publicado em 2014

Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

Por Müller, Maximilian, Lee, Ciaran M, Gasiunas, Giedrius, Davis, Timothy H, Cradick, Thomas J, Siksnys, Virginijus, Bao, Gang, Cathomen, Toni, Mussolino, Claudio
Publicado no Mol Ther (2016)

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

Por Lin, Yanni, Cradick, Thomas J., Brown, Matthew T., Deshmukh, Harshavardhan, Ranjan, Piyush, Sarode, Neha, Wile, Brian M., Vertino, Paula M., Stewart, Frank J., Bao, Gang
Publicado em 2014

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

Por Ramirez, Cherie L., Certo, Michael T., Mussolino, Claudio, Goodwin, Mathew J., Cradick, Thomas J., McCaffrey, Anton P., Cathomen, Toni, Scharenberg, Andrew M., Joung, J. Keith
Publicado em 2012

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

Por Ye, Lin, Wang, Jiaming, Beyer, Ashley I., Teque, Fernando, Cradick, Thomas J., Qi, Zhongxia, Chang, Judy C., Bao, Gang, Muench, Marcus O., Yu, Jingwei, Levy, Jay A., Kan, Yuet Wai
Publicado em 2014

DNA targeting specificity of RNA-guided Cas9 nucleases

Por Hsu, Patrick D, Scott, David A, Weinstein, Joshua A, Ran, F Ann, Konermann, Silvana, Agarwala, Vineeta, Li, Yinqing, Fine, Eli J, Wu, Xuebing, Shalem, Ophir, Cradick, Thomas J, Marraffini, Luciano A, Bao, Gang, Zhang, Feng
Publicado em 2013

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

Por Suzuki, Shingo, Sargent, R Geoffrey, Illek, Beate, Fischer, Horst, Esmaeili-Shandiz, Alaleh, Yezzi, Michael J, Lee, Albert, Yang, Yanu, Kim, Soya, Renz, Peter, Qi, Zhongxia, Yu, Jingwei, Muench, Marcus O, Beyer, Ashley I, Guimarães, Alessander O, Ye, Lin, Chang, Judy, Fine, Eli J, Cradick, Thomas J, Bao, Gang, Rahdar, Meghdad, Porteus, Matthew H, Shuto, Tsuyoshi, Kai, Hirofumi, Kan, Yuet W, Gruenert, Dieter C
Publicado no Mol Ther Nucleic Acids (2016)