Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome

RNA-guided nucleases (RGNs) based on the type II CRISPR-Cas9 system of Streptococcus pyogenes (Sp) have been widely used for genome editing in experimental models. However, the nontrivial level of off-target activity reported in several human cells may hamper clinical translation. RGN specificity de...

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Müller, Maximilian, Lee, Ciaran M, Gasiunas, Giedrius, Davis, Timothy H, Cradick, Thomas J, Siksnys, Virginijus, Bao, Gang, Cathomen, Toni, Mussolino, Claudio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786917/
https://ncbi.nlm.nih.gov/pubmed/26658966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.218
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