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Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome
RNA-guided nucleases (RGNs) based on the type II CRISPR-Cas9 system of Streptococcus pyogenes (Sp) have been widely used for genome editing in experimental models. However, the nontrivial level of off-target activity reported in several human cells may hamper clinical translation. RGN specificity de...
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| Опубликовано в: : | Mol Ther |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4786917/ https://ncbi.nlm.nih.gov/pubmed/26658966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.218 |
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