In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus

Clustered regularly interspaced short palindromic repeats (CRISPR)-encoded immunity in Type I systems relies on the Cascade (CRISPR-associated complex for antiviral defence) ribonucleoprotein complex, which triggers foreign DNA degradation by an accessory Cas3 protein. To establish the mechanism for...

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Autori principali: Sinkunas, Tomas, Gasiunas, Giedrius, Waghmare, Sakharam P, Dickman, Mark J, Barrangou, Rodolphe, Horvath, Philippe, Siksnys, Virginijus
Natura: Artigo
Lingua:Inglês
Pubblicazione: European Molecular Biology Organization 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567492/
https://ncbi.nlm.nih.gov/pubmed/23334296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.352
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