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CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

The ability to precisely modify endogenous genes can significantly facilitate biological studies and disease treatment, and the clustered regularly interspaced short palindromic repeats (CRISPR) systems have the potential to be powerful tools for genome engineering. However, the target specificity o...

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Autors principals: Cradick, Thomas J., Fine, Eli J., Antico, Christopher J., Bao, Gang
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814385/
https://ncbi.nlm.nih.gov/pubmed/23939622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt714
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