Quantifying On and Off-Target Genome Editing

por Hendel, Ayal, Fine, Eli J, Bao, Gang, Porteus, Matthew H
Publicado en Trends Biotechnol (2015)

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

por Cradick, Thomas J., Fine, Eli J., Antico, Christopher J., Bao, Gang
Publicado 2013

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

por Lee, Ciaran M, Cradick, Thomas J, Fine, Eli J, Bao, Gang
Publicado en Mol Ther (2016)

Nanomedicine: Tiny Particles and Machines Give Huge Gains

por Tong, Sheng, Fine, Eli J., Lin, Yanni, Cradick, Thomas J., Bao, Gang
Publicado 2013

An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

por Fine, Eli J., Cradick, Thomas J., Zhao, Charles L., Lin, Yanni, Bao, Gang
Publicado 2014

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

por Cradick, Thomas J, Qiu, Peng, Lee, Ciaran M, Fine, Eli J, Bao, Gang
Publicado en Mol Ther Nucleic Acids (2014)

TALENs facilitate targeted genome editing in human cells with high specificity and low cytotoxicity

por Mussolino, Claudio, Alzubi, Jamal, Fine, Eli J., Morbitzer, Robert, Cradick, Thomas J., Lahaye, Thomas, Bao, Gang, Cathomen, Toni
Publicado 2014

Trans-spliced Cas9 allows cleavage of HBB and CCR5 genes in human cells using compact expression cassettes

por Fine, Eli J., Appleton, Caleb M., White, Douglas E., Brown, Matthew T., Deshmukh, Harshavardhan, Kemp, Melissa L., Bao, Gang
Publicado en Sci Rep (2015)

Quantifying Genome Editing Outcomes at Endogenous Loci using SMRT Sequencing

por Hendel, Ayal, Kildebeck, Eric J, Fine, Eli J, Clark, Joseph, Punjya, Niraj, Sebastiano, Vittorio, Bao, Gang, Porteus, Matthew H
Publicado 2014

Preclinical Development of a Hematopoietic Stem and Progenitor Cell Bioengineered Factor VIII Lentiviral Vector Gene Therapy for Hemophilia A

por Doering, Christopher B., Denning, Gabriela, Shields, Jordan E., Fine, Eli J., Parker, Ernest T., Srivastava, Alok, Lollar, Pete, Spencer, H. Trent
Publicado en Hum Gene Ther (2018)

SAPTA: a new design tool for improving TALE nuclease activity

por Lin, Yanni, Fine, Eli J., Zheng, Zhilan, Antico, Christopher J., Voit, Richard A., Porteus, Matthew H., Cradick, Thomas J., Bao, Gang
Publicado 2014

DNA targeting specificity of RNA-guided Cas9 nucleases

por Hsu, Patrick D, Scott, David A, Weinstein, Joshua A, Ran, F Ann, Konermann, Silvana, Agarwala, Vineeta, Li, Yinqing, Fine, Eli J, Wu, Xuebing, Shalem, Ophir, Cradick, Thomas J, Marraffini, Luciano A, Bao, Gang, Zhang, Feng
Publicado 2013

CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep

por Vilarino, Marcela, Rashid, Sheikh Tamir, Suchy, Fabian Patrik, McNabb, Bret Roberts, van der Meulen, Talitha, Fine, Eli J., Ahsan, Syed Daniyal, Mursaliyev, Nurlybek, Sebastiano, Vittorio, Diab, Santiago Sain, Huising, Mark O., Nakauchi, Hiromitsu, Ross, Pablo J.
Publicado en Sci Rep (2017)

Author Correction: CRISPR/Cas9 microinjection in oocytes disables pancreas development in sheep

por Vilarino, Marcela, Rashid, Sheikh Tamir, Suchy, Fabian Patrik, McNabb, Bret Roberts, van der Meulen, Talitha, Fine, Eli J., Ahsan, Syed Daniyal, Mursaliyev, Nurlybek, Sebastiano, Vittorio, Diab, Santiago Sain, Huising, Mark O., Nakauchi, Hiromitsu, Ross, Pablo J.
Publicado en Sci Rep (2020)

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

por Suzuki, Shingo, Sargent, R Geoffrey, Illek, Beate, Fischer, Horst, Esmaeili-Shandiz, Alaleh, Yezzi, Michael J, Lee, Albert, Yang, Yanu, Kim, Soya, Renz, Peter, Qi, Zhongxia, Yu, Jingwei, Muench, Marcus O, Beyer, Ashley I, Guimarães, Alessander O, Ye, Lin, Chang, Judy, Fine, Eli J, Cradick, Thomas J, Bao, Gang, Rahdar, Meghdad, Porteus, Matthew H, Shuto, Tsuyoshi, Kai, Hirofumi, Kan, Yuet W, Gruenert, Dieter C
Publicado en Mol Ther Nucleic Acids (2016)