Advancements in gene transfer-based therapy for hemophilia A

Tekijä Doering, Christopher B, Spencer, H Trent
Julkaistu 2009

Delivery of nucleic acid therapeutics by genetically engineered hematopoietic stem cells

Tekijä Doering, Christopher B., Archer, David, Spencer, H. Trent
Julkaistu 2010

Enhanced Biosynthesis of Coagulation Factor VIII through Diminished Engagement of the Unfolded Protein Response

Tekijä Brown, Harrison C., Gangadharan, Bagirath, Doering, Christopher B.
Julkaistu 2011

Engineered Hematopoietic Stem Cells as Therapeutics for Hemophilia A

Tekijä Zakas, Philip M., Spencer, H. Trent, Doering, Christopher B.
Julkaisussa J Genet Syndr Gene Ther (2011)

Potentiation of Thrombin Generation in Hemophilia A Plasma by Coagulation Factor VIII and Characterization of Antibody-Specific Inhibition

Tekijä Doshi, Bhavya S., Gangadharan, Bagirath, Doering, Christopher B., Meeks, Shannon L.
Julkaistu 2012

Generation of an Optimized Lentiviral Vector Encoding a High-Expression Factor VIII Transgene for Gene Therapy of Hemophilia A

Tekijä Johnston, Jennifer M., Denning, Gabriela, Doering, Christopher B., Spencer, H. Trent
Julkaistu 2012

The Immune Response to the fVIII Gene Therapy in Preclinical Models

Tekijä Patel, Seema R., Lundgren, Taran S., Spencer, H. Trent, Doering, Christopher B.
Julkaisussa Front Immunol (2020)

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens

Tekijä Ide, Lucienne M., Gangadharan, Bagirath, Chiang, Kuang-Yueh, Doering, Christopher B., Spencer, H. Trent
Julkaistu 2007

High-level protein production in erythroid cells derived from in vivo transduced hematopoietic stem cells

Tekijä Wang, Hongjie, Liu, Zhinan, Li, Chang, Gil, Sucheol, Papayannopoulou, Thalia, Doering, Christopher B., Lieber, André
Julkaisussa Blood Adv (2019)

Human serum albumin and chromatin condensation rescue ex vivo expanded γδ T cells from the effects of cryopreservation

Tekijä Burnham, Rebecca E., Tope, Donald, Branella, Gianna, Williams, Erich, Doering, Christopher B., Spencer, H. Trent
Julkaisussa Cryobiology (2021)

Development and Characterization of Recombinant Ovine Coagulation Factor VIII

Tekijä Zakas, Philip M., Gangadharan, Bagirath, Almeida-Porada, Graca, Porada, Christopher D., Spencer, H. Trent, Doering, Christopher B.
Julkaistu 2012

Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A

Tekijä Brown, Harrison C., Zakas, Philip M., George, Stephan N., Parker, Ernest T., Spencer, H. Trent, Doering, Christopher B.
Julkaisussa Mol Ther Methods Clin Dev (2018)

Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells

Tekijä Fleischer, Lauren C., Becker, Scott A., Ryan, Rebecca E., Fedanov, Andrew, Doering, Christopher B., Spencer, H. Trent
Julkaisussa Mol Ther Oncolytics (2020)

Lentiviral Gene Therapy for Familial Hemophagocytic Lymphohistiocytosis Type 3, Caused by UNC13D Genetic Defects

Tekijä Takushi, Sarah E., Paik, Na Yoon, Fedanov, Andrew, Prince, Chengyu, Doering, Christopher B., Spencer, H. Trent, Chandrakasan, Shanmuganathan
Julkaisussa Hum Gene Ther (2020)

Unaccompanied mechanosensory domain mediates low expression of glycoprotein Ibα: Implications for Bernard-Soulier syndrome

Tekijä Tao, Yue, Gan, Chi, Zhang, Xiaoqin, Liu, Lanbo, Zakas, Philip M., Doering, Christopher B., Mo, Xi, Li, Renhao
Julkaisussa J Thromb Haemost (2019)

Genetic engineering of chimeric antigen receptors using lamprey derived variable lymphocyte receptors

Tekijä Moot, Robert, Raikar, Sunil S, Fleischer, Lauren, Querrey, Melissa, Tylawsky, Daniel E, Nakahara, Hirotomo, Doering, Christopher B, Spencer, H Trent
Julkaisussa Mol Ther Oncolytics (2016)

Ex vivo expanded patient-derived γδ T-cell immunotherapy enhances neuroblastoma tumor regression in a murine model

Tekijä Zoine, Jaquelyn T., Knight, Kristopher A., Fleischer, Lauren C., Sutton, Kathryn S., Goldsmith, Kelly C., Doering, Christopher B., Spencer, H. Trent
Julkaisussa Oncoimmunology (2019)

Bortezomib enhances cytotoxicity of ex vivo expanded gamma delta (γδ) T cells against AML and T-ALL

Tekijä Story, Jamie Y., Zoine, Jaquelyn T., Ryan, Becca E., Hamilton, Jamie A., Spencer, H. Trent, Doering, Christopher B., Raikar, Sunil S.
Julkaisussa Cytotherapy (2020)

Comparison of Factor VIII Transgenes Bioengineered for Improved Expression in Gene Therapy of Hemophilia A

Tekijä Dooriss, Kerry L., Denning, Gabriela, Gangadharan, Bagirath, Javazon, Elisabeth H., McCarty, David A., Spencer, H. Trent, Doering, Christopher B.
Julkaistu 2009

Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery

Tekijä Brown, Harrison C, Wright, J Fraser, Zhou, Shangzhen, Lytle, Allison M, Shields, Jordan E, Spencer, H Trent, Doering, Christopher B
Julkaisussa Mol Ther Methods Clin Dev (2014)