High-level protein production in erythroid cells derived from in vivo transduced hematopoietic stem cells

We developed an in vivo hematopoietic stem cell (HSC) transduction approach that involves HSC mobilization from the bone marrow into the peripheral bloodstream and the IV injection of an integrating, helper-dependent adenovirus (HDAd5/35(++)) vector system. HDAd5/35(++) vectors target human CD46, a...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Wang, Hongjie, Liu, Zhinan, Li, Chang, Gil, Sucheol, Papayannopoulou, Thalia, Doering, Christopher B., Lieber, André
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6784527/
https://ncbi.nlm.nih.gov/pubmed/31585952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000706
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