Hemophilia and inhibitors: current treatment options and potential new therapeutic approaches

von Meeks, Shannon L., Batsuli, Glaivy
Veröffentlicht in Hematology Am Soc Hematol Educ Program (2016)

The evolution of factor VIIa in the treatment of bleeding in haemophilia with inhibitors

von Meeks, Shannon L., Leissinger, Cindy A.
Veröffentlicht in Haemophilia (2019)

Emerging benefits of Fc fusion technology in the context of recombinant factor VIII replacement therapy

von Meeks, Shannon L., Lacroix‐Desmazes, Sébastien
Veröffentlicht in Haemophilia (2020)

Potentiation of Thrombin Generation in Hemophilia A Plasma by Coagulation Factor VIII and Characterization of Antibody-Specific Inhibition

von Doshi, Bhavya S., Gangadharan, Bagirath, Doering, Christopher B., Meeks, Shannon L.
Veröffentlicht 2012

Emicizumab in tolerized patients with hemophilia A with inhibitors: A single‐institution pediatric cohort assessing inhibitor status

von Batsuli, Glaivy, Greene, Amanda, Meeks, Shannon L., Sidonio, Robert F.
Veröffentlicht in Res Pract Thromb Haemost (2021)

Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation

von Meeks, Shannon L., Healey, John F., Parker, Ernest T., Barrow, Rachel T., Lollar, Pete
Veröffentlicht 2007

Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors

von Meeks, Shannon L., Healey, John F., Parker, Ernest T., Barrow, Rachel T., Lollar, Pete
Veröffentlicht 2008

Non-Classical Anti-Factor VIII C2 Domain Antibodies Are Pathogenic in a Murine in vivo Bleeding Model

von Meeks, Shannon L., Healey, John F., Parker, Ernest T., Barrow, Rachel T., Lollar, Pete
Veröffentlicht 2009

The diversity of the immune response to the A2 domain of human factor VIII

von Markovitz, Rebecca C., Healey, John F., Parker, Ernest T., Meeks, Shannon L., Lollar, Pete
Veröffentlicht 2013

Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry

von Sevy, Alexander M., Healey, John F., Deng, Wei, Spiegel, P. Clint, Meeks, Shannon L., Li, Renhao
Veröffentlicht 2013

A subset of high-titer anti–factor VIII A2 domain antibodies is responsive to treatment with factor VIII

von Eubanks, Joshua, Baldwin, W. Hunter, Markovitz, Rebecca, Parker, Ernest T., Cox, Courtney, Kempton, Christine L., Meeks, Shannon L.
Veröffentlicht in Blood (2016)

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

von Meeks, Shannon L., Cox, Courtney L., Healey, John F., Parker, Ernest T., Doshi, Bhavya S., Gangadharan, Bagirath, Barrow, Rachel T., Lollar, Pete
Veröffentlicht 2012

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

von Zakas, Philip M., Brown, Harrison C., Knight, Kristopher, Meeks, Shannon L., Spencer, H. Trent, Gaucher, Eric A., Doering, Christopher B.
Veröffentlicht in Nat Biotechnol (2016)

Characterization and Solution Structure of the Factor VIII C2 Domain in a Ternary Complex with Classical and Non-classical Inhibitor Antibodies

von Walter, Justin D., Werther, Rachel A., Polozova, Maria S., Pohlman, Julie, Healey, John F., Meeks, Shannon L., Lollar, Pete, Spiegel, P. Clint
Veröffentlicht 2013

Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein

von Summers, Ryan J., Meeks, Shannon L., Healey, John F., Brown, Harrison C., Parker, Ernest T., Kempton, Christine L., Doering, Christopher B., Lollar, Pete
Veröffentlicht 2011

Marginal zone B cells are critical to factor VIII inhibitor formation in mice with hemophilia A

von Zerra, Patricia E., Cox, Courtney, Baldwin, W. Hunter, Patel, Seema R., Arthur, Connie M., Lollar, Pete, Meeks, Shannon L., Stowell, Sean R.
Veröffentlicht in Blood (2017)

Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes

von Walter, Justin D., Werther, Rachel A., Brison, Caileen M., Cragerud, Rebecca K., Healey, John F., Meeks, Shannon L., Lollar, Pete, Spiegel, P. Clint
Veröffentlicht 2013

B cell–activating factor modulates the factor VIII immune response in hemophilia A

von Doshi, Bhavya S., Rana, Jyoti, Castaman, Giancarlo, Shaheen, Mostafa A., Kaczmarek, Radoslaw, Butterfield, John S.S., Meeks, Shannon L., Leissinger, Cindy, Biswas, Moanaro, Arruda, Valder R.
Veröffentlicht in J Clin Invest (2021)

High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance

von Nguyen, Phuong-Cac T., Lewis, Kenneth B., Ettinger, Ruth A., Schuman, Jason T., Lin, Jasper C., Healey, John F., Meeks, Shannon L., Lollar, Pete, Pratt, Kathleen P.
Veröffentlicht 2014

The 1.7 Å X-Ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces

von Brison, Caileen M., Mullen, Steven M., Wuerth, Michelle E., Podolsky, Kira, Cook, Matthew, Herman, Jacob A., Walter, Justin D., Meeks, Shannon L., Spiegel, P. Clint
Veröffentlicht in PLoS One (2015)