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The diversity of the immune response to the A2 domain of human factor VIII
Approximately 30% of patients with severe hemophilia A develop inhibitory anti–factor VIII (fVIII) antibodies (Abs). We characterized 29 anti-human A2 monoclonal Abs (mAbs) produced in a murine hemophilia A model. A basis set of nonoverlapping mAbs was defined by competition enzyme-linked immunosorb...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617638/ https://ncbi.nlm.nih.gov/pubmed/23349389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-456582 |
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