Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors

The antihuman factor VIII (fVIII) C2 domain immune response in hemophilia A mice consists of antibodies that can be divided into 5 groups of structural epitopes and 2 groups of functional epitopes. Groups A, AB, and B consist of classical C2 antibodies that inhibit the binding of fVIII to phospholip...

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Bibliographic Details
Main Authors: Meeks, Shannon L., Healey, John F., Parker, Ernest T., Barrow, Rachel T., Lollar, Pete
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2008
Subjects:
Hemostasis, Thrombosis, and Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515124/
https://ncbi.nlm.nih.gov/pubmed/18495957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-132639
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