Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors

Antzeko izenburuak

• Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation
  nork: Meeks, Shannon L., et al.
  Argitaratua: (2007)
• Non-Classical Anti-Factor VIII C2 Domain Antibodies Are Pathogenic in a Murine in vivo Bleeding Model
  nork: Meeks, Shannon L., et al.
  Argitaratua: (2009)
• Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes
  nork: Walter, Justin D., et al.
  Argitaratua: (2013)
• The diversity of the immune response to the A2 domain of human factor VIII
  nork: Markovitz, Rebecca C., et al.
  Argitaratua: (2013)
• A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function
  nork: Meeks, Shannon L., et al.
  Argitaratua: (2012)