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A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function
A main complication of treatment of patients with hemophilia A is the development of anti–factor VIII (fVIII) antibodies. The immunogenicity of fVIII potentially is a function of its procoagulant activity, which may result in danger signals that drive the immune response. Alternatively, intrinsic st...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3448263/ https://ncbi.nlm.nih.gov/pubmed/22855607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-412361 |
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