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A subset of high-titer anti–factor VIII A2 domain antibodies is responsive to treatment with factor VIII

The primary B-cell epitopes of factor VIII (fVIII) are in the A2 and C2 domains. Within the C2 domain, antibody epitope and kinetics are more important than inhibitor titer in predicting pathogenicity in a murine bleeding model. To investigate this within the A2 domain, the pathogenicity of a divers...

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發表在:Blood
Main Authors: Eubanks, Joshua, Baldwin, W. Hunter, Markovitz, Rebecca, Parker, Ernest T., Cox, Courtney, Kempton, Christine L., Meeks, Shannon L.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841042/
https://ncbi.nlm.nih.gov/pubmed/26825708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-670034
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