A subset of high-titer anti–factor VIII A2 domain antibodies is responsive to treatment with factor VIII

The primary B-cell epitopes of factor VIII (fVIII) are in the A2 and C2 domains. Within the C2 domain, antibody epitope and kinetics are more important than inhibitor titer in predicting pathogenicity in a murine bleeding model. To investigate this within the A2 domain, the pathogenicity of a divers...

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Publicado en:Blood
Autores principales: Eubanks, Joshua, Baldwin, W. Hunter, Markovitz, Rebecca, Parker, Ernest T., Cox, Courtney, Kempton, Christine L., Meeks, Shannon L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2016
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841042/
https://ncbi.nlm.nih.gov/pubmed/26825708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-670034
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