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A subset of high-titer anti–factor VIII A2 domain antibodies is responsive to treatment with factor VIII
The primary B-cell epitopes of factor VIII (fVIII) are in the A2 and C2 domains. Within the C2 domain, antibody epitope and kinetics are more important than inhibitor titer in predicting pathogenicity in a murine bleeding model. To investigate this within the A2 domain, the pathogenicity of a divers...
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| Publicado en: | Blood |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society of Hematology
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4841042/ https://ncbi.nlm.nih.gov/pubmed/26825708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-09-670034 |
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