A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

A main complication of treatment of patients with hemophilia A is the development of anti–factor VIII (fVIII) antibodies. The immunogenicity of fVIII potentially is a function of its procoagulant activity, which may result in danger signals that drive the immune response. Alternatively, intrinsic st...

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Detalhes bibliográficos
Main Authors: Meeks, Shannon L., Cox, Courtney L., Healey, John F., Parker, Ernest T., Doshi, Bhavya S., Gangadharan, Bagirath, Barrow, Rachel T., Lollar, Pete
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448263/
https://ncbi.nlm.nih.gov/pubmed/22855607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-412361
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