The diversity of the immune response to the A2 domain of human factor VIII

Approximately 30% of patients with severe hemophilia A develop inhibitory anti–factor VIII (fVIII) antibodies (Abs). We characterized 29 anti-human A2 monoclonal Abs (mAbs) produced in a murine hemophilia A model. A basis set of nonoverlapping mAbs was defined by competition enzyme-linked immunosorb...

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Hlavní autoři: Markovitz, Rebecca C., Healey, John F., Parker, Ernest T., Meeks, Shannon L., Lollar, Pete
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617638/
https://ncbi.nlm.nih.gov/pubmed/23349389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-456582
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