Marginal zone B cells are critical to factor VIII inhibitor formation in mice with hemophilia A

Although factor VIII (FVIII) replacement therapy can be lifesaving for patients with hemophilia A, neutralizing alloantibodies to FVIII, known as inhibitors, develop in a significant number of patients and actively block FVIII activity, making bleeding difficult to control and prevent. Although a va...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zerra, Patricia E., Cox, Courtney, Baldwin, W. Hunter, Patel, Seema R., Arthur, Connie M., Lollar, Pete, Meeks, Shannon L., Stowell, Sean R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5721282/
https://ncbi.nlm.nih.gov/pubmed/28978569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-782912
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