High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors

Inhibitor formation in hemophilia A is the most feared treatment-related complication of factor VIII (fVIII) therapy. Most inhibitor patients with hemophilia A develop antibodies against the fVIII A2 and C2 domains. Recent evidence demonstrates that the C1 domain contributes to the inhibitor respons...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Batsuli, Glaivy, Deng, Wei, Healey, John F., Parker, Ernest T., Baldwin, W. Hunter, Cox, Courtney, Nguyen, Brenda, Kahle, Joerg, Königs, Christoph, Li, Renhao, Lollar, Pete, Meeks, Shannon L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073184/
https://ncbi.nlm.nih.gov/pubmed/27381905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-701805
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