The 1.7 Å X-Ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces

The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may sponta...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Brison, Caileen M., Mullen, Steven M., Wuerth, Michelle E., Podolsky, Kira, Cook, Matthew, Herman, Jacob A., Walter, Justin D., Meeks, Shannon L., Spiegel, P. Clint
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4361576/
https://ncbi.nlm.nih.gov/pubmed/25775247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122447
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