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Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry

BACKGROUND: The development of anti-factor VIII (fVIII) antibodies (inhibitors) is a significant complication in the management of patients with hemophilia A, leading to significant increases in morbidity and treatment cost. Using a panel of anti-fVIII monoclonal antibodies (MAbs) to different epito...

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Detalhes bibliográficos
Main Authors: Sevy, Alexander M., Healey, John F., Deng, Wei, Spiegel, P. Clint, Meeks, Shannon L., Li, Renhao
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947443/
https://ncbi.nlm.nih.gov/pubmed/24152306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.12433
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