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Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C

Human cystatin C (hCC) is a small cysteine protease inhibitor whose oligomerization by propagated domain swapping is linked to certain neurological disorders. One of the ways to prevent hCC dimerization and fibrillogenesis is to enable its interaction with a proper antibody. Herein, the sites of int...

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Publicat a:Amino Acids
Autors principals: Prądzińska, Martyna, Behrendt, Izabela, Astorga-Wells, Juan, Manoilov, Aleksandr, Zubarev, Roman A., Kołodziejczyk, Aleksandra S., Rodziewicz-Motowidło, Sylwia, Czaplewska, Paulina
Format: Artigo
Idioma:Inglês
Publicat: Springer Vienna 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107209/
https://ncbi.nlm.nih.gov/pubmed/27573935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-016-2316-y
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