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Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C

Human cystatin C (hCC) is a small cysteine protease inhibitor whose oligomerization by propagated domain swapping is linked to certain neurological disorders. One of the ways to prevent hCC dimerization and fibrillogenesis is to enable its interaction with a proper antibody. Herein, the sites of int...

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Dettagli Bibliografici
Pubblicato in:Amino Acids
Autori principali: Prądzińska, Martyna, Behrendt, Izabela, Astorga-Wells, Juan, Manoilov, Aleksandr, Zubarev, Roman A., Kołodziejczyk, Aleksandra S., Rodziewicz-Motowidło, Sylwia, Czaplewska, Paulina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Vienna 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107209/
https://ncbi.nlm.nih.gov/pubmed/27573935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-016-2316-y
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