Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C

Human cystatin C (hCC) is a small cysteine protease inhibitor whose oligomerization by propagated domain swapping is linked to certain neurological disorders. One of the ways to prevent hCC dimerization and fibrillogenesis is to enable its interaction with a proper antibody. Herein, the sites of int...

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Bibliografske podrobnosti
izdano v:Amino Acids
Main Authors: Prądzińska, Martyna, Behrendt, Izabela, Astorga-Wells, Juan, Manoilov, Aleksandr, Zubarev, Roman A., Kołodziejczyk, Aleksandra S., Rodziewicz-Motowidło, Sylwia, Czaplewska, Paulina
Format: Artigo
Jezik:Inglês
Izdano: Springer Vienna 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107209/
https://ncbi.nlm.nih.gov/pubmed/27573935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-016-2316-y
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