Structural Insights into Fibrinogen Dynamics Using Amide Hydrogen/Deuterium Exchange Mass Spectrometry

We determined the amide hydrogen/deuterium exchange profile of native human fibrinogen under physiologic conditions. After optimization of the quench and proteolysis conditions, more than 1,200 peptides were identified by mass spectrometry, spanning more than 90% of the constituent Aα, Bβ, and γ cha...

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Bibliografiske detaljer
Main Authors: Marsh, James J., Guan, Henry S., Li, Sheng, Chiles, Peter G., Tran, Danny, Morris, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821761/
https://ncbi.nlm.nih.gov/pubmed/23875785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4007995
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