Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution

Hydrogen-deuterium exchange (HDX) coupled with mass spectrometry (HDXMS) is a rapid and effective method for localizing and determining protein stability and dynamics. Localization is routinely limited to a peptide resolution of 5 to 20 amino acid residues. HDXMS data can contain information beyond...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Gessner, Chris, Steinchen, Wieland, Bédard, Sabrina, J. Skinner, John, Woods, Virgil L., Walsh, Thomas J., Bange, Gert, Pantazatos, Dionysios P.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476592/
https://ncbi.nlm.nih.gov/pubmed/28630467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03922-3
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