Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

Individuals homozygous for the C-C chemokine receptor type 5 gene with 32-bp deletions (CCR5Δ32) are resistant to HIV-1 infection. In this study, we generated induced pluripotent stem cells (iPSCs) homozygous for the naturally occurring CCR5Δ32 mutation through genome editing of wild-type iPSCs usin...

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Detalhes bibliográficos
Main Authors: Ye, Lin, Wang, Jiaming, Beyer, Ashley I., Teque, Fernando, Cradick, Thomas J., Qi, Zhongxia, Chang, Judy C., Bao, Gang, Muench, Marcus O., Yu, Jingwei, Levy, Jay A., Kan, Yuet Wai
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4084478/
https://ncbi.nlm.nih.gov/pubmed/24927590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407473111
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