The Case for Selection at CCR5-Δ32

The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Δ32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Δ32 arose within the past 1,000 y and rose to its present high frequency (5%–14%) in Europe as a result of strong positive sel...

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Detalhes bibliográficos
Main Authors: Sabeti, Pardis C, Walsh, Emily, Schaffner, Steve F, Varilly, Patrick, Fry, Ben, Hutcheson, Holli B, Cullen, Mike, Mikkelsen, Tarjei S, Roy, Jessica, Patterson, Nick, Cooper, Richard, Reich, David, Altshuler, David, O'Brien, Stephen, Lander, Eric S
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1275522/
https://ncbi.nlm.nih.gov/pubmed/16248677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0030378
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