The Case for Selection at CCR5-Δ32

The C-C chemokine receptor 5, 32 base-pair deletion (CCR5-Δ32) allele confers strong resistance to infection by the AIDS virus HIV. Previous studies have suggested that CCR5-Δ32 arose within the past 1,000 y and rose to its present high frequency (5%–14%) in Europe as a result of strong positive sel...

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Autores principales: Sabeti, Pardis C, Walsh, Emily, Schaffner, Steve F, Varilly, Patrick, Fry, Ben, Hutcheson, Holli B, Cullen, Mike, Mikkelsen, Tarjei S, Roy, Jessica, Patterson, Nick, Cooper, Richard, Reich, David, Altshuler, David, O'Brien, Stephen, Lander, Eric S
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1275522/
https://ncbi.nlm.nih.gov/pubmed/16248677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0030378
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