Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

Engineered zinc finger nucleases (ZFNs) induce DNA double-strand breaks at specific recognition sequences and can promote efficient introduction of desired insertions, deletions or substitutions at or near the cut site via homology-directed repair (HDR) with a double- and/or single-stranded donor DN...

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Detalhes bibliográficos
Main Authors: Ramirez, Cherie L., Certo, Michael T., Mussolino, Claudio, Goodwin, Mathew J., Cradick, Thomas J., McCaffrey, Anton P., Cathomen, Toni, Scharenberg, Andrew M., Joung, J. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384306/
https://ncbi.nlm.nih.gov/pubmed/22373919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks179
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