Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion

Zinc-finger nucleases (ZFNs) have been successfully used for rational genome engineering in a variety of cell types and organisms. ZFNs consist of a non-specific FokI endonuclease domain and a specific zinc-finger DNA-binding domain. Because the catalytic domain must dimerize to become active, two Z...

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Bibliographische Detailangaben
Hauptverfasser: Şöllü, Cem, Pars, Kaweh, Cornu, Tatjana I., Thibodeau-Beganny, Stacey, Maeder, Morgan L., Joung, J. Keith, Heilbronn, Regine, Cathomen, Toni
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001086/
https://ncbi.nlm.nih.gov/pubmed/20716517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq720
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