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Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion
Zinc-finger nucleases (ZFNs) have been successfully used for rational genome engineering in a variety of cell types and organisms. ZFNs consist of a non-specific FokI endonuclease domain and a specific zinc-finger DNA-binding domain. Because the catalytic domain must dimerize to become active, two Z...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3001086/ https://ncbi.nlm.nih.gov/pubmed/20716517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq720 |
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