Versatile and Efficient Genome Editing in Human Cells by Combining Zinc-Finger Nucleases With Adeno-Associated Viral Vectors

Zinc-finger nucleases (ZFNs) have become a valuable tool for targeted genome engineering. Based on the enzyme's ability to create a site-specific DNA double-strand break, ZFNs promote genome editing by activating the cellular DNA damage response, including homology-directed repair (HDR) and non...

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Autors principals: Händel, Eva-Maria, Gellhaus, Katharina, Khan, Kafaitullah, Bednarski, Christien, Cornu, Tatjana I., Müller-Lerch, Felix, Kotin, Robert M., Heilbronn, Regine, Cathomen, Toni
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3300077/
https://ncbi.nlm.nih.gov/pubmed/21980922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.140
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