The Nontoxic Cell Cycle Modulator Indirubin Augments Transduction of Adeno-Associated Viral Vectors and Zinc-Finger Nuclease-Mediated Gene Targeting

Parameters that regulate or affect the cell cycle or the DNA repair choice between non-homologous end-joining and homology-directed repair (HDR) are excellent targets to enhance therapeutic gene targeting. Here, we have evaluated the impact of five cell-cycle modulating drugs on targeted genome engi...

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Hlavní autoři: Rahman, Shamim H., Bobis-Wozowicz, Sylwia, Chatterjee, Debanjana, Gellhaus, Katharina, Pars, Kaweh, Heilbronn, Regine, Jacobs, Roland, Cathomen, Toni
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2013
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555098/
https://ncbi.nlm.nih.gov/pubmed/23072634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.168
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