Selection-Independent Generation of Gene Knockout Mouse Embryonic Stem Cells Using Zinc-Finger Nucleases

Gene knockout in murine embryonic stem cells (ESCs) has been an invaluable tool to study gene function in vitro or to generate animal models with altered phenotypes. Gene targeting using standard techniques, however, is rather inefficient and typically does not exceed frequencies of 10(−6). In conse...

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Bibliografiske detaljer
Main Authors: Osiak, Anna, Radecke, Frank, Guhl, Eva, Radecke, Sarah, Dannemann, Nadine, Lütge, Fabienne, Glage, Silke, Rudolph, Cornelia, Cantz, Tobias, Schwarz, Klaus, Heilbronn, Regine, Cathomen, Toni
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237556/
https://ncbi.nlm.nih.gov/pubmed/22194948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028911
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