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A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
Sequence-specific nucleases represent valuable tools for precision genome engineering. Traditionally, zinc-finger nucleases (ZFNs) and meganucleases have been used to specifically edit complex genomes. Recently, the DNA binding domains of transcription activator-like effectors (TALEs) from the bacte...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3241638/ https://ncbi.nlm.nih.gov/pubmed/21813459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr597 |
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