A Novel SERCA Inhibitor Demonstrates Synergy with Classic SERCA Inhibitors and Targets Multidrug-Resistant AML

Por Bleeker, Nicholas P., Cornea, Razvan L., Thomas, David D., Xing, Chengguo
Publicado em 2013

Functional and Physical Competition between Phospholamban and its Mutants Provides Insight into the Molecular Mechanism of Gene Therapy for Heart Failure

Por Lockamy, Elizabeth L., Cornea, Razvan L., Karim, Christine B., Thomas, David D.
Publicado em 2011

Mapping the Ryanodine Receptor FK506-binding Protein Subunit Using Fluorescence Resonance Energy Transfer

Por Cornea, Razvan L., Nitu, Florentin R., Samsó, Montserrat, Thomas, David D., Fruen, Bradley R.
Publicado em 2010

N-terminal and Central Segments of the Type 1 Ryanodine Receptor Mediate Its Interaction with FK506-binding Proteins

Por Girgenrath, Tanya, Mahalingam, Mohana, Svensson, Bengt, Nitu, Florentin R., Cornea, Razvan L., Fessenden, James D.
Publicado em 2013

Structural mapping of divergent regions in the type 1 ryanodine receptor using fluorescence resonance energy transfer

Por Mahalingam, Mohana, Girgenrath, Tanya, Svensson, Bengt, Thomas, David D., Cornea, Razvan L., Fessenden, James D.
Publicado em 2014

FRET-based mapping of calmodulin bound to the RyR1 Ca(2+) release channel

Por Cornea, Razvan L., Nitu, Florentin, Gruber, Simon, Kohler, Katherine, Satzer, Michael, Thomas, David D., Fruen, Bradley R.
Publicado em 2009

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex

Por Rebbeck, Robyn T., Nitu, Florentin R., Rohde, David, Most, Patrick, Bers, Donald M., Thomas, David D., Cornea, Razvan L.
Publicado no J Biol Chem (2016)

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks

Por Guo, Tao, Cornea, Razvan L., Huke, Sabine, Camors, Emmanuel, Yang, Yi, Picht, Eckard, Fruen, Bradley R., Bers, Donald M.
Publicado em 2010

FRET Detection of Calmodulin Binding to the Cardiac RyR2 Calcium Release Channel

Por Guo, Tao, Fruen, Bradley R., Nitu, Florentin R., Nguyen, Trinh D., Yang, Yi, Cornea, Razvan L., Bers, Donald M.
Publicado em 2011

Binding of RyR2 “Unzipping” Peptide in Cardiomyocytes Activates RyR2 and Reciprocally Inhibits Calmodulin Binding

Por Oda, Tetsuro, Yang, Yi, Nitu, Florentin R., Svensson, Bengt, Lu, Xiyuan, Fruen, Bradley R., Cornea, Razvan L., Bers, Donald M.
Publicado em 2012

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant

Por Yuchi, Zhiguang, Yuen, Siobhan M. Wong King, Lau, Kelvin, Underhill, Ainsley Q., Cornea, Razvan L., Fessenden, James D., Van Petegem, Filip
Publicado no Nat Commun (2015)

High-Throughput Screens to Discover Small-Molecule Modulators of Ryanodine Receptor Calcium Release Channels

Por Rebbeck, Robyn T., Essawy, Maram M., Nitu, Florentin R., Grant, Benjamin D., Gillispie, Gregory D., Thomas, David D., Bers, Donald M., Cornea, Razvan L.
Publicado no SLAS Discov (2016)

Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity

Por Oda, Tetsuro, Yang, Yi, Uchinoumi, Hitoshi, Thomas, David D., Chen-Izu, Ye, Kato, Takayoshi, Yamamoto, Takeshi, Yano, Masafumi, Cornea, Razvan L., Bers, Donald M.
Publicado no J Mol Cell Cardiol (2015)

Cardiac Myocyte Z-line Calmodulin is Mainly RyR2-Bound and Reduction is Arrhythmogenic and Occurs in Heart Failure

Por Yang, Yi, Guo, Tao, Oda, Tetsuro, Chakraborty, Asima, Chen, Le, Uchinoumi, Hitoshi, Knowlton, Anne A., Fruen, Bradley R., Cornea, Razvan L., Meissner, Gerhard, Bers, Donald M.
Publicado em 2013

FRET-Based Trilateration of Probes Bound within Functional Ryanodine Receptors

Por Svensson, Bengt, Oda, Tetsuro, Nitu, Florentin R., Yang, Yi, Cornea, Iustin, Chen-Izu, Ye, Fessenden, James D., Bers, Donald M., Thomas, David D., Cornea, Razvan L.
Publicado no Biophys J (2014)

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

Por Uchinoumi, Hitoshi, Yang, Yi, Oda, Tetsuro, Li, Na, Alsina, Katherina M., Puglisi, Jose L., Chen-Izu, Ye, Cornea, Razvan L., Wehrens, Xander H.T., Bers, Donald M.
Publicado no J Mol Cell Cardiol (2016)

Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells

Por Gruber, Simon J., Cornea, Razvan L., Li, Ji, Peterson, Kurt C., Schaaf, Tory M., Gillispie, Gregory D., Dahl, Russell, Zsebo, Krisztina M., Robia, Seth L., Thomas, David D.
Publicado em 2014

High-Throughput FRET Assay Yields Allosteric SERCA Activators

Por Cornea, Razvan L., Lockamy, Elizabeth L., Gruber, Simon J., Muretta, Joseph M., Jin, Dongzhu, Chen, Jiqiu, Dahl, Russell, Bartfai, Tamas, Zsebo, Krisztina M., Gillispie, Gregory D., Thomas, David D.
Publicado em 2012

Divergent Regulation of Ryr2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

Por Hwang, Hyun-Seok, Nitu, Florentin R, Yang, Yi, Walweel, Kafa, Pereira, Laetitia, Johnson, Christopher N, Faggioni, Michela, Chazin, Walter J, Laver, Derek, George, Alfred L, Cornea, Razvan L, Bers, Donald M, Knollmann, Björn C
Publicado em 2014

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks

Por Gomez-Hurtado, Nieves, Boczek, Nicole J., Kryshtal, Dmytro O., Johnson, Christopher N., Sun, Jennifer, Nitu, Florentin R., Cornea, Razvan L., Chazin, Walter J., Calvert, Melissa L., Tester, David J., Ackerman, Michael J., Knollmann, Bjorn C.
Publicado no Circ Arrhythm Electrophysiol (2016)