Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks

BACKGROUND: Calmodulin (CaM) mutations are associated with severe forms of long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). We recently reported that CaM mutations were found in 13% of genotype-negative LQTS patients, but the prevalence of CaM mutations in ge...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Gomez-Hurtado, Nieves, Boczek, Nicole J., Kryshtal, Dmytro O., Johnson, Christopher N., Sun, Jennifer, Nitu, Florentin R., Cornea, Razvan L., Chazin, Walter J., Calvert, Melissa L., Tester, David J., Ackerman, Michael J., Knollmann, Bjorn C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4988333/
https://ncbi.nlm.nih.gov/pubmed/27516456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.116.004161
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