Divergent Regulation of Ryr2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

RATIONALE: Calmodulin (CaM) mutations are associated with an autosomal-dominant syndrome of ventricular arrhythmia and sudden death that can present with divergent clinical features of catecholaminergic polymorphic ventricular tachycardia (CPVT)or long QT syndrome (LQTS).CaM binds to and inhibits Ry...

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Hauptverfasser: Hwang, Hyun-Seok, Nitu, Florentin R, Yang, Yi, Walweel, Kafa, Pereira, Laetitia, Johnson, Christopher N, Faggioni, Michela, Chazin, Walter J, Laver, Derek, George, Alfred L, Cornea, Razvan L, Bers, Donald M, Knollmann, Björn C
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990285/
https://ncbi.nlm.nih.gov/pubmed/24563457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.303391
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