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Binding of RyR2 “Unzipping” Peptide in Cardiomyocytes Activates RyR2 and Reciprocally Inhibits Calmodulin Binding
RATIONALE: One hypothesis for elevated Ca(2+) leak through cardiac ryanodine receptors (RyR2) in heart failure (HF) is interdomain “unzipping” that can enhance aberrant channel activation. A peptide (DPc10) corresponding to RyR2 central domain 2460-2495 recapitulates this arrhythmogenic RyR2 leakine...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3573756/ https://ncbi.nlm.nih.gov/pubmed/23233753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300290 |
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