Nalaganje...
Binding of RyR2 “Unzipping” Peptide in Cardiomyocytes Activates RyR2 and Reciprocally Inhibits Calmodulin Binding
RATIONALE: One hypothesis for elevated Ca(2+) leak through cardiac ryanodine receptors (RyR2) in heart failure (HF) is interdomain “unzipping” that can enhance aberrant channel activation. A peptide (DPc10) corresponding to RyR2 central domain 2460-2495 recapitulates this arrhythmogenic RyR2 leakine...
Shranjeno v:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3573756/ https://ncbi.nlm.nih.gov/pubmed/23233753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.300290 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|