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Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity

Oxidative stress may contribute to cardiac ryanodine receptor (RyR2) dysfunction in heart failure (HF) and arrhythmias. Altered RyR2 domain-domain interaction (domain unzipping) and calmodulin (CaM) binding affinity are allosterically coupled indices of RyR2 conformation. In HF RyR2 exhibits reduced...

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Vydáno v:	J Mol Cell Cardiol
Hlavní autoři:	Oda, Tetsuro, Yang, Yi, Uchinoumi, Hitoshi, Thomas, David D., Chen-Izu, Ye, Kato, Takayoshi, Yamamoto, Takeshi, Yano, Masafumi, Cornea, Razvan L., Bers, Donald M.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2015
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4530019/ https://ncbi.nlm.nih.gov/pubmed/26092277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.06.009
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Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity

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