CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

Diastolic calcium (Ca) leak via cardiac ryanodine receptors (RyR2) can cause arrhythmias and heart failure (HF). Ca/calmodulin (CaM)-dependent kinase II (CaMKII) is upregulated and more active in HF, promoting RyR2-mediated Ca leak by RyR2-Ser2814 phosphorylation. Here, we tested a mechanistic hypot...

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Publicat a:J Mol Cell Cardiol
Autors principals: Uchinoumi, Hitoshi, Yang, Yi, Oda, Tetsuro, Li, Na, Alsina, Katherina M., Puglisi, Jose L., Chen-Izu, Ye, Cornea, Razvan L., Wehrens, Xander H.T., Bers, Donald M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026590/
https://ncbi.nlm.nih.gov/pubmed/27318036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.06.007
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