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CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift
Diastolic calcium (Ca) leak via cardiac ryanodine receptors (RyR2) can cause arrhythmias and heart failure (HF). Ca/calmodulin (CaM)-dependent kinase II (CaMKII) is upregulated and more active in HF, promoting RyR2-mediated Ca leak by RyR2-Ser2814 phosphorylation. Here, we tested a mechanistic hypot...
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Publicado no: | J Mol Cell Cardiol |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026590/ https://ncbi.nlm.nih.gov/pubmed/27318036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.06.007 |
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