S-Nitrosylation Induces Both Autonomous Activation and Inhibition of Calcium/Calmodulin-dependent Protein Kinase II δ

di Erickson, Jeffrey R., Nichols, C. Blake, Uchinoumi, Hitoshi, Stein, Matthew L., Bossuyt, Julie, Bers, Donald M.
Pubblicato in J Biol Chem (2015)

Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity

di Oda, Tetsuro, Yang, Yi, Uchinoumi, Hitoshi, Thomas, David D., Chen-Izu, Ye, Kato, Takayoshi, Yamamoto, Takeshi, Yano, Masafumi, Cornea, Razvan L., Bers, Donald M.
Pubblicato in J Mol Cell Cardiol (2015)

Comparison of diagnostic performance in assessing the rewiring position into a jailed side branch between online 3D reconstruction systems version 1.1 and 1.2 derived from optical...

di Fujimura, Tatsuhiro, Okamura, Takayuki, Furuya, Kazuki, Miyazaki, Yosuke, Takenaka, Hitoshi, Tateishi, Hiroki, Oda, Tetsuro, Mochizuki, Mamoru, Uchinoumi, Hitoshi, Nishimura, Takashi, Yamada, Jutaro, Yano, Masafumi
Pubblicato in Cardiovasc Interv Ther (2019)

Cardiac Myocyte Z-line Calmodulin is Mainly RyR2-Bound and Reduction is Arrhythmogenic and Occurs in Heart Failure

di Yang, Yi, Guo, Tao, Oda, Tetsuro, Chakraborty, Asima, Chen, Le, Uchinoumi, Hitoshi, Knowlton, Anne A., Fruen, Bradley R., Cornea, Razvan L., Meissner, Gerhard, Bers, Donald M.
Pubblicazione 2013

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

di Uchinoumi, Hitoshi, Yang, Yi, Oda, Tetsuro, Li, Na, Alsina, Katherina M., Puglisi, Jose L., Chen-Izu, Ye, Cornea, Razvan L., Wehrens, Xander H.T., Bers, Donald M.
Pubblicato in J Mol Cell Cardiol (2016)

Ryanodine receptor–bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia

di Nakamura, Yoshihide, Yamamoto, Takeshi, Kobayashi, Shigeki, Tamitani, Masaki, Hamada, Yoriomi, Fukui, Go, Xu, Xiaojuan, Nishimura, Shigehiko, Kato, Takayoshi, Uchinoumi, Hitoshi, Oda, Tetsuro, Okuda, Shinichi, Yano, Masafumi
Pubblicato in JCI Insight (2019)

Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca(2+) level and ER stress

di Tamitani, Masaki, Yamamoto, Takeshi, Yamamoto, Naoki, Fujisawa, Koichi, Tanaka, Shinji, Nakamura, Yoshihide, Uchinoumi, Hitoshi, Oda, Tetsuro, Okuda, Shinichi, Takami, Taro, Kobayashi, Shigeki, Sakaida, Isao, Yano, Masafumi
Pubblicato in Biochem Biophys Rep (2020)

Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine r...

di Kobayashi, Shigeki, Yano, Masafumi, Suetomi, Takeshi, Ono, Makoto, Tateishi, Hiroki, Mochizuki, Mamoru, Xu, Xiaojuan, Uchinoumi, Hitoshi, Okuda, Shinichi, Yamamoto, Takeshi, Koseki, Noritaka, Kyushiki, Hiroyuki, Ikemoto, Noriaki, Matsuzaki, Masunori
Pubblicazione 2009

Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

di Kohno, Michiaki, Kobayashi, Shigeki, Yamamoto, Takeshi, Yoshitomi, Ryosuke, Kajii, Toshiro, Fujii, Shohei, Nakamura, Yoshihide, Kato, Takayoshi, Uchinoumi, Hitoshi, Oda, Tetsuro, Okuda, Shinichi, Watanabe, Kenji, Mizukami, Yoichi, Yano, Masafumi
Pubblicato in Commun Biol (2020)

Defective domain–domain interactions within the ryanodine receptor as a critical cause of diastolic Ca(2+) leak in failing hearts

di Tateishi, Hiroki, Yano, Masafumi, Mochizuki, Mamoru, Suetomi, Takeshi, Ono, Makoto, Xu, Xiaojuan, Uchinoumi, Hitoshi, Okuda, Shinichi, Oda, Tetsuro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ohkusa, Tomoko, Ikemoto, Noriaki, Matsuzaki, Masunori
Pubblicazione 2009

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

di Xu, Xiaojuan, Yano, Masafumi, Uchinoumi, Hitoshi, Hino, Akihiro, Suetomi, Takeshi, Ono, Makoto, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ikemoto, Noriaki, Matsuzaki, Masunori
Pubblicazione 2010

Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor

di Uchinoumi, Hitoshi, Yano, Masafumi, Suetomi, Takeshi, Ono, Makoto, Xu, Xiaojuan, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ohkusa, Tomoko, Ikemoto, Noriaki, Matsuzaki, Masunori
Pubblicazione 2010

Mutation-Linked Defective Inter-Domain Interactions within Ryanodine Receptor Cause Aberrant Ca(2+) Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia

di Suetomi, Takeshi, Yano, Masafumi, Uchinoumi, Hitoshi, Fukuda, Masakazu, Hino, Akihiro, Ono, Makoto, Xu, Xiaojuan, Tateishi, Hiroki, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Ikeda, Yasuhiho, Yamamoto, Takeshi, Ikemoto, Noriaki, Matsuzaki, Masunori
Pubblicazione 2011

Nuclear Translocation of Calmodulin in Pathological Cardiac Hypertrophy Originates from Ryanodine Receptor bound Calmodulin

di Oda, Tetsuro, Yamamoto, Takeshi, Kato, Takayoshi, Uchinoumi, Hitoshi, Fukui, Go, Hamada, Yoriomi, Nanno, Takuma, Ishiguchi, Hironori, Nakamura, Yoshihide, Okamoto, Yoko, Kono, Michiaki, Okuda, Shinichi, Kobayashi, Shigeki, Bers, Donald M., Yano, Masafumi
Pubblicato in J Mol Cell Cardiol (2018)

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure

di Ono, Makoto, Yano, Masafumi, Hino, Akihiro, Suetomi, Takeshi, Xu, Xiaojuan, Susa, Takehisa, Uchinoumi, Hitoshi, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Koseki, Noritaka, Kyushiki, Hiroyuki, Ikemoto, Noriaki, Matsuzaki, Masunori
Pubblicazione 2010

A Low-Dose β1-Blocker in Combination with Milrinone Improves Intracellular Ca(2+) Handling in Failing Cardiomyocytes by Inhibition of Milrinone-Induced Diastolic Ca(2+) Leakage fro...

di Kobayashi, Shigeki, Susa, Takehisa, Ishiguchi, Hironori, Myoren, Takeki, Murakami, Wakako, Kato, Takayoshi, Fukuda, Masakazu, Hino, Akihiro, Suetomi, Takeshi, Ono, Makoto, Uchinoumi, Hitoshi, Tateishi, Hiroki, Mochizuki, Mamoru, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Yamamoto, Takeshi, Yano, Masafumi
Pubblicato in PLoS One (2015)