Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure

AIMS: Calmodulin (CaM) is well known to modulate the channel function of the cardiac ryanodine receptor (RyR2). However, the possible role of CaM on the aberrant Ca(2+) release in diseased hearts remains unclear. In this study, we investigated the state of RyR2-bound CaM and channel dysfunctions in...

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Detalhes bibliográficos
Main Authors: Ono, Makoto, Yano, Masafumi, Hino, Akihiro, Suetomi, Takeshi, Xu, Xiaojuan, Susa, Takehisa, Uchinoumi, Hitoshi, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Koseki, Noritaka, Kyushiki, Hiroyuki, Ikemoto, Noriaki, Matsuzaki, Masunori
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025723/
https://ncbi.nlm.nih.gov/pubmed/20388639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq108
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