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Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine receptor
OBJECTIVES: To investigate the effect of dantrolene, a drug generally used to treat Malignant Hyperthermia (MH), on the Ca(2+) release and cardiomyocyte function in failing hearts. BACKGROUND: The N-terminal (N: 1-600) and Central (C: 2000-2500) domains of the ryanodine receptor (RyR), harbor many m...
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| Main Authors: | , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764410/ https://ncbi.nlm.nih.gov/pubmed/19460614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2009.01.065 |
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