Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine receptor

OBJECTIVES: To investigate the effect of dantrolene, a drug generally used to treat Malignant Hyperthermia (MH), on the Ca(2+) release and cardiomyocyte function in failing hearts. BACKGROUND: The N-terminal (N: 1-600) and Central (C: 2000-2500) domains of the ryanodine receptor (RyR), harbor many m...

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Autori principali: Kobayashi, Shigeki, Yano, Masafumi, Suetomi, Takeshi, Ono, Makoto, Tateishi, Hiroki, Mochizuki, Mamoru, Xu, Xiaojuan, Uchinoumi, Hitoshi, Okuda, Shinichi, Yamamoto, Takeshi, Koseki, Noritaka, Kyushiki, Hiroyuki, Ikemoto, Noriaki, Matsuzaki, Masunori
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2764410/
https://ncbi.nlm.nih.gov/pubmed/19460614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2009.01.065
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