Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor

RATIONALE: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in a well-defined region of the cardiac type-2 ryanodine receptor (RyR2). However, the underlying mechanism by which a single mutation in such a large molecule produces drastic effects on cha...

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Main Authors: Uchinoumi, Hitoshi, Yano, Masafumi, Suetomi, Takeshi, Ono, Makoto, Xu, Xiaojuan, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ohkusa, Tomoko, Ikemoto, Noriaki, Matsuzaki, Masunori
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862146/
https://ncbi.nlm.nih.gov/pubmed/20224043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.209312
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