Mutation-Linked Defective Inter-Domain Interactions within Ryanodine Receptor Cause Aberrant Ca(2+) Release Leading to Catecholaminergic Polymorphic Ventricular Tachycardia

BACKGROUND: The molecular mechanism by which catecholaminergic polymorphic ventricular tachycardia (CPVT) is induced by single amino acid mutations within the cardiac ryanodine receptor (RyR2) remains elusive. Here, we investigated mutation-induced conformational defects of RyR2 using a knock-in (KI...

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Main Authors: Suetomi, Takeshi, Yano, Masafumi, Uchinoumi, Hitoshi, Fukuda, Masakazu, Hino, Akihiro, Ono, Makoto, Xu, Xiaojuan, Tateishi, Hiroki, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Ikeda, Yasuhiho, Yamamoto, Takeshi, Ikemoto, Noriaki, Matsuzaki, Masunori
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153588/
https://ncbi.nlm.nih.gov/pubmed/21768539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.023259
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