Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

Calmodulin (CaM), one of the accessory proteins of the cardiac ryanodine receptor (RyR2), is known to play a significant role in the channel regulation of the RyR2. However, the possible involvement of calmodulin in the pathogenic process of catecholaminergic polymorphic ventricular tachycardia (CPV...

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Main Authors: Xu, Xiaojuan, Yano, Masafumi, Uchinoumi, Hitoshi, Hino, Akihiro, Suetomi, Takeshi, Ono, Makoto, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ikemoto, Noriaki, Matsuzaki, Masunori
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858291/
https://ncbi.nlm.nih.gov/pubmed/20226167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2010.03.046
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