Defective domain–domain interactions within the ryanodine receptor as a critical cause of diastolic Ca(2+) leak in failing hearts

AIMS: A domain peptide (DP) matching the Gly(2460)–Pro(2495) region of the cardiac type-2 ryanodine receptor (RyR2), DPc10, is known to mimic channel dysfunction associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), owing to its interference in a normal interaction of the N-t...

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Main Authors: Tateishi, Hiroki, Yano, Masafumi, Mochizuki, Mamoru, Suetomi, Takeshi, Ono, Makoto, Xu, Xiaojuan, Uchinoumi, Hitoshi, Okuda, Shinichi, Oda, Tetsuro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ohkusa, Tomoko, Ikemoto, Noriaki, Matsuzaki, Masunori
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2009
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Original Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721653/
https://ncbi.nlm.nih.gov/pubmed/18996969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvn303
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