Binding of RyR2 “Unzipping” Peptide in Cardiomyocytes Activates RyR2 and Reciprocally Inhibits Calmodulin Binding

Por Oda, Tetsuro, Yang, Yi, Nitu, Florentin R., Svensson, Bengt, Lu, Xiyuan, Fruen, Bradley R., Cornea, Razvan L., Bers, Donald M.
Publicado em 2012

Oxidation of Ryanodine Receptor (RyR) and Calmodulin enhance Ca release and pathologically alter RyR structure and Calmodulin affinity

Por Oda, Tetsuro, Yang, Yi, Uchinoumi, Hitoshi, Thomas, David D., Chen-Izu, Ye, Kato, Takayoshi, Yamamoto, Takeshi, Yano, Masafumi, Cornea, Razvan L., Bers, Donald M.
Publicado no J Mol Cell Cardiol (2015)

Cardiac Myocyte Z-line Calmodulin is Mainly RyR2-Bound and Reduction is Arrhythmogenic and Occurs in Heart Failure

Por Yang, Yi, Guo, Tao, Oda, Tetsuro, Chakraborty, Asima, Chen, Le, Uchinoumi, Hitoshi, Knowlton, Anne A., Fruen, Bradley R., Cornea, Razvan L., Meissner, Gerhard, Bers, Donald M.
Publicado em 2013

FRET-Based Trilateration of Probes Bound within Functional Ryanodine Receptors

Por Svensson, Bengt, Oda, Tetsuro, Nitu, Florentin R., Yang, Yi, Cornea, Iustin, Chen-Izu, Ye, Fessenden, James D., Bers, Donald M., Thomas, David D., Cornea, Razvan L.
Publicado no Biophys J (2014)

CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift

Por Uchinoumi, Hitoshi, Yang, Yi, Oda, Tetsuro, Li, Na, Alsina, Katherina M., Puglisi, Jose L., Chen-Izu, Ye, Cornea, Razvan L., Wehrens, Xander H.T., Bers, Donald M.
Publicado no J Mol Cell Cardiol (2016)

Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca(2+) Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Is...

Por Murakami, Wakako, Kobayashi, Shigeki, Susa, Takehisa, Nanno, Takuma, Ishiguchi, Hironori, Myoren, Takeki, Nishimura, Shigehiko, Kato, Takayoshi, Hino, Akihiro, Oda, Tetsuro, Okuda, Shinichi, Yamamoto, Takeshi, Yano, Masafumi
Publicado no PLoS One (2016)

Defective domain–domain interactions within the ryanodine receptor as a critical cause of diastolic Ca(2+) leak in failing hearts

Por Tateishi, Hiroki, Yano, Masafumi, Mochizuki, Mamoru, Suetomi, Takeshi, Ono, Makoto, Xu, Xiaojuan, Uchinoumi, Hitoshi, Okuda, Shinichi, Oda, Tetsuro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ohkusa, Tomoko, Ikemoto, Noriaki, Matsuzaki, Masunori
Publicado em 2009

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

Por Xu, Xiaojuan, Yano, Masafumi, Uchinoumi, Hitoshi, Hino, Akihiro, Suetomi, Takeshi, Ono, Makoto, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ikemoto, Noriaki, Matsuzaki, Masunori
Publicado em 2010

Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor

Por Uchinoumi, Hitoshi, Yano, Masafumi, Suetomi, Takeshi, Ono, Makoto, Xu, Xiaojuan, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Ikeda, Yasuhiro, Ohkusa, Tomoko, Ikemoto, Noriaki, Matsuzaki, Masunori
Publicado em 2010

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure

Por Ono, Makoto, Yano, Masafumi, Hino, Akihiro, Suetomi, Takeshi, Xu, Xiaojuan, Susa, Takehisa, Uchinoumi, Hitoshi, Tateishi, Hiroki, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Koseki, Noritaka, Kyushiki, Hiroyuki, Ikemoto, Noriaki, Matsuzaki, Masunori
Publicado em 2010

A Low-Dose β1-Blocker in Combination with Milrinone Improves Intracellular Ca(2+) Handling in Failing Cardiomyocytes by Inhibition of Milrinone-Induced Diastolic Ca(2+) Leakage fro...

Por Kobayashi, Shigeki, Susa, Takehisa, Ishiguchi, Hironori, Myoren, Takeki, Murakami, Wakako, Kato, Takayoshi, Fukuda, Masakazu, Hino, Akihiro, Suetomi, Takeshi, Ono, Makoto, Uchinoumi, Hitoshi, Tateishi, Hiroki, Mochizuki, Mamoru, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Yamamoto, Takeshi, Yano, Masafumi
Publicado no PLoS One (2015)