A Low-Dose β1-Blocker in Combination with Milrinone Improves Intracellular Ca(2+) Handling in Failing Cardiomyocytes by Inhibition of Milrinone-Induced Diastolic Ca(2+) Leakage from the Sarcoplasmic Reticulum

OBJECTIVES: The purpose of this study was to investigate whether adding a low-dose β1-blocker to milrinone improves cardiac function in failing cardiomyocytes and the underlying cardioprotective mechanism. BACKGROUND: The molecular mechanism underlying how the combination of low-dose β1-blocker and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kobayashi, Shigeki, Susa, Takehisa, Ishiguchi, Hironori, Myoren, Takeki, Murakami, Wakako, Kato, Takayoshi, Fukuda, Masakazu, Hino, Akihiro, Suetomi, Takeshi, Ono, Makoto, Uchinoumi, Hitoshi, Tateishi, Hiroki, Mochizuki, Mamoru, Oda, Tetsuro, Okuda, Shinichi, Doi, Masahiro, Yamamoto, Takeshi, Yano, Masafumi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304815/
https://ncbi.nlm.nih.gov/pubmed/25614983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114314
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