Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts

AIMS: The channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, the involvement of CaM in aberrant Ca(2+) release in diseased hearts remains unclear. Here, we investigated the pathogenic role of defective CaM binding to the RyR2 in the channel dysfuncti...

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Bibliographic Details
Main Authors: Hino, Akihiro, Yano, Masafumi, Kato, Takayoshi, Fukuda, Masakazu, Suetomi, Takeshi, Ono, Makoto, Murakami, Wakako, Susa, Takehisa, Okuda, Shinichi, Doi, Masahiro, Kobayashi, Shigeki, Yamamoto, Takeshi, Koseki, Noritaka, Kyushiki, Hiroyuki, Ikemoto, Noriaki, Matsuzaki, Masunori
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584972/
https://ncbi.nlm.nih.gov/pubmed/22893680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs271
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