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Inhibition of CaMKII Phosphorylation of RyR2 Prevents Inducible Ventricular Arrhythmias in Mice with Duchenne Muscular Dystrophy
BACKGROUND: Ventricular tachycardia (VT) is the second most common cause of death in patients with Duchenne muscular dystrophy (DMD). Recent studies have implicated enhanced sarcoplasmic reticulum (SR) Ca(2+) leak via ryanodine receptors (RyR2) as a cause of VT in the mdx mouse model of DMD. However...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605194/ https://ncbi.nlm.nih.gov/pubmed/23246599 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2012.12.016 |
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