Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

Calmodulin (CaM) is a Ca-binding protein that binds to, and can directly inhibit cardiac ryanodine receptor calcium release channels (RyR2). Animal studies have shown that RyR2 hyperphosphorylation reduces CaM binding to RyR2 in failing hearts, but data are lacking on how CaM regulates human RyR2 an...

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Publicat a:J Mol Cell Cardiol
Autors principals: Walweel, Kafa, Gomez-Hurtado, Nieves, Rebbeck, Robyn T, Oo, Ye Wint, Beard, Nicole A, Molenaar, Peter, dos Remedios, Cris, van Helden, Dirk F, Cornea, Razvan L, Knollmann, Björn C, Laver, Derek R
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791359/
https://ncbi.nlm.nih.gov/pubmed/30928430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.03.018
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