Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

Calmodulin (CaM) is a Ca-binding protein that binds to, and can directly inhibit cardiac ryanodine receptor calcium release channels (RyR2). Animal studies have shown that RyR2 hyperphosphorylation reduces CaM binding to RyR2 in failing hearts, but data are lacking on how CaM regulates human RyR2 an...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Walweel, Kafa, Gomez-Hurtado, Nieves, Rebbeck, Robyn T, Oo, Ye Wint, Beard, Nicole A, Molenaar, Peter, dos Remedios, Cris, van Helden, Dirk F, Cornea, Razvan L, Knollmann, Björn C, Laver, Derek R
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791359/
https://ncbi.nlm.nih.gov/pubmed/30928430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.03.018
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