Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814

Calmodulin (CaM) is a Ca-binding protein that binds to, and can directly inhibit cardiac ryanodine receptor calcium release channels (RyR2). Animal studies have shown that RyR2 hyperphosphorylation reduces CaM binding to RyR2 in failing hearts, but data are lacking on how CaM regulates human RyR2 an...

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Detaylı Bibliyografya
Yayımlandı:J Mol Cell Cardiol
Asıl Yazarlar: Walweel, Kafa, Gomez-Hurtado, Nieves, Rebbeck, Robyn T, Oo, Ye Wint, Beard, Nicole A, Molenaar, Peter, dos Remedios, Cris, van Helden, Dirk F, Cornea, Razvan L, Knollmann, Björn C, Laver, Derek R
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791359/
https://ncbi.nlm.nih.gov/pubmed/30928430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.03.018
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