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Essential Role of Calmodulin in RyR Inhibition by Dantrolene
Dantrolene is the first line therapy of malignant hyperthermia. Animal studies suggest that dantrolene also protects against heart failure and arrhythmias caused by spontaneous Ca(2+) release. Although dantrolene inhibits Ca(2+) release from the sarcoplasmic reticulum of skeletal and cardiac muscle...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4468648/ https://ncbi.nlm.nih.gov/pubmed/25920678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.097691 |
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